They combine many advantages of drug carrier systems. Comparative study of sustainedrelease lipid microparticles. Formulation and release characteristics of zidovudine bioline. All measure ments were performed in triplicate at a temperature of 25. Lipid coated chitosan microparticles as protein carriers. Preparation, characterization and evaluation of moisturizing and uv protecting effects of topical solid lipid nanoparticles 685 and zeta potential of the sln formulations.
Techniques for the preparation of solid lipid nano and. Slms combine many advantages of drug carrier systems. Slms combine the advantages of different traditional carriers. Formulation of inhalable lipidbased salbutamol sulfate. Solid lipid nanoparticles slns are the first generation of lipidbased nanocarriers that are formulated from lipids, which are solid in the body temperature and.
Therefore, the lipid magnetic particles produced by our modifiedpgss process have properties which are suitable for future use in biomedical application. Lorenzo rodriguez university of bologna consorzio tefarco innova interest in solid lipid microparticles slms is relatively recent and relates to the developments in the past. The purpose of this study was to improve the solubilization, bioavailability, and permeability of hydrochlorothiazide hctz by the formulation and characterization of hctz solid lipid microparticles slms based on fat derived from irvingia gabonensis var. The lipid core is stabilized by surfactants emulsifiers.
The tests were performed in triplicate, with the results shown being the average of the obtained values. A solid lipid nanoparticle is typically spherical with an average diameter between 10 and nanometers. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of bioactive compounds and their transfer to the site of. Solid lipid nanoparticles slns have attracted increasing attention during recent years. Ir study of pure drug, stearic acid and drug loaded solid lipid microparticle were. The resultant substance is then ground to obtain lipid microparticles 50100.
Determination of ibuprofen content using uvvis spectrophotometry for the determination of ibuprofen content in solid dispersions and lipid microparticles, 75 mg of each sample. The supernatant was then diluted with methanol and analyzed by uvvis spectrophotometer at 233 nm using a model 71, electronics india. Voriconazole is a secondgeneration antifungal agent with excellent broad spectrum of antifungal activity commercially available for oral and intravenous administration. It has been proposed that slns combine the advantages of traditional colloidal. Aspirinloaded solid lipid microparticles slms were formulated by hot homogenization and analysed for their encapsulation efficiency ee%, in vitro release, particle size, antiinflammatory and ulcer inhibition properties. Solid lipid microdispersions slms based on pegylated solidified. Systemic administration of voriconazole is associated with side effects including visual and hepatic abnormalities. The particle formation unit was designed and custom built in our laboratory. The entrapment efficacy of nanoparticle was calculated as follows. Solid lipid nanoparticles sln, colloidal drug carriers, homogenization, tem, pcs, biodistribution, targeting.
There are different techniques for the preparation of solid lipid nanoand microparticles. Formulation and characterization of hydrochlorothiazide solid. All components were weighted into sealed containers and heated to 80 c. First, the advantages of slms compared with other drug carrier systems are listed. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of. Slns combine the advantages and avoid the drawbacks. Design and evaluation of voriconazole loaded solid lipid. These solid lipid microparticles are then dispersed in cold surfactant solution. Solid lipid nanoparticles preparation and characterization. The term coacervationwas suggested for the first time by two dutch scientists38.
Solid lipid nanoparticles sln are at the forefront of the rapidly developing field of. These lipid microparticles are dispersed in a cold surfactant solution yielding a presuspension and homogenized at or below room. The slmps were prepared by using two different solvent systems ethanol and waterethanol and lipid carriers dipalmitoylphosphatidylcholine dppc and cholesterol withwithout lleucine. The effects of pressure 122, 211 and 300 bar and nozzle diameter 0. Journal of global trends in pharmaceutical sciences. The invention is related to compositions which can be used as dermal formulations for supporting the skin to restore normal conditions in case of e.
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Solid lipid nanoparticles as colloidal drug carrier systems antonio j. Then an overview of slm manufacturing compounds and techniques is presented. These particles can be composed of different types of solid lipids, such as glycerides, waxes, and fatty acids, and stabilized by a wide range of surfactants. This study assessed the feasibility of using solid lipid nanoparticles for ocular delivery of voriconazole.
Then the drug lipid mixture is rapidlycooled either by means of liquid nitrogen or dry ice. Formulation and evaluation of acyclovir sodium solid lipid microparticles anantha naik nagappa, gaurav agarwal, vinuth chikkamath, shilpi agarwal, rekha rani and pk karar date of receipt 122016 date of revision 15122016 date of acceptance 27122016 address for correspondence scs college of pharmacy, harapanahalli5831, karnataka, india. Formulation and evaluation of solid lipid nanoparticle sln. Slns combine all the advantages of polymeric nanoparticles, fat. Slns combine the advantages and avoid the disadvantages of the other colloidal carriers liposomes, emulsions, and polymeric micro and nanoparticles 8. Production of lipid microparticles magnetically active by a.
Please cite this article in press as umeyo r ce et al. Solid lipid nanoparticles sln are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Jun 11, 2014 the aim of this work was to develop dry powder inhaler dpi formulations of salbutamol sulfate ss by the aid of solid lipid microparticles slmps, composed of biocompatible phospholipids or cholesterol. Preparation, characterization and evaluation of moisturizing. Slns act as a new colloidal drug carrier for intravenous applications. Solid lipid nanoparticle an overview sciencedirect topics. Emulsions can be used as precursors for solid lipid particles preparation since lipids, that are solid at room temperature, can be heated 510 c above their melting point to obtain a liquid lipid that can be emulsified with water at the same temperature. Preparation and characterization of solid lipid nanoparticles. Solid lipid microparticles slms combine the advantages of different traditional carriers. These are the types of carriers which not only combine the. The ability to incorporate drugs into nanoparticles offers a new prototype in drug delivery thus realizing the dual goal of both controlled release and sitespecific drug delivery. Slns combine all the advantages of polymeric nanoparticles, fat emulsions and liposomes. A simple and green process based on supercritical carbon dioxide scco 2 technology was used to produce solid lipid microparticles from fully hydrogenated canola oil fhco. Slns are colloidal carriers developed in the last decade as an alternative system to the existing traditional carriers emulsions, liposomes and polymeric nanoparticles.
Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics. Solid lipid nanoparticles possess a solid lipid core matrix that can solubilize lipophilic molecules. Nanoparticles of magnetite were coated with lipids to form lipid nano and microparticles by a modifiedpgss technique carried out at moderate temperature. Rizatriptan loaded sln were prepared by modified solvent injection method and characterized for shape, surface morphology, particle size, and drug entrapment. Solid lipid nanoparticles sln are a new generation of drug delivery systems being exploited for several drugs since the nineties. The lipid microparticles are then suspended in a cold aqueous surfactant solution to obtain a presuspension. Microemulsion based method slns can be produced by microemulsification of molten lipids, as the internal phase and subsequent dispersion of the microemulsion in aqueous medium under mechanical stirring. In a first step, spherically shaped chitosan particles were produced by spray. The drug containing solid lipid is milled bymeans of mortar or ball mill to micron size 50100 micron and these microparticles aredispersed in chilled emulsifier solution yielding a presuspension. Solid lipid nanoparticles are one of the novel potential colloidal carrier systems as alternative materials to polymers which is identical to oil in water emulsion for parenteral nutrition, but the liquid lipid of the emulsion has been replaced by a solid lipid shown on fig. The yield of microparticles should have the desired size range and the drug encapsulation efficiency should be high. Production, characterisation and release profiles, food research international on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
These lipid nanoparticles are known as solid lipid nanoparticles slns, which are attracting wide attention of formulators worldwide 2. In multicellular organisms, microvesicles and other evs are found both in tissues in the interstitial space between cells and in many types of body fluids. Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine, and research, as well as in other varied sciences. Solid lipid microparticles, drug delivery, lipidbased, drug encapsulation. Aspirinloaded solid lipid microparticles slms were formulated by hot homogenization and. Specific objectives were to develop hollow solid lipid micro and nanoparticles using scco 2 technology, and to load the hollow solid lipid micro and nanoparticles with essential oil to develop food grade freeflowing powder. Formulation, preparation, characterisation, drug release. Us20120128777a1 compositions containing lipid micro or. An effective lipid based technology for controlled drug delivery. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. Where ee is entrapment efficiency, wa stands for the mass of. Solid lipid nanoparticles and nanostructured lipid carriers as novel. Then this presuspension is homogenized at or below room temperature, the gravitation force is strong. Solid lipid nanoparticles authorstream presentation.
Solid lipid nanoparticles a promising drug delivery system. The drug is dissolved, dispersed, or solubilized in the hot melted lipid followed by cooling to room temperature. Preparation and characterization of rizatriptan loaded solid. Formulation and evaluation of acyclovir sodium solid lipid. The prepared lipid microparticles are then dispersed in a cold emulsifier solution at or below room temperature. Solid lipid nanoparticles thesis pdf development, characterization and evaluation of solid lipid nanoparticles as a potential. I velopments of the solid lipid nanoparticles slns according to the recent relevant literatures. Solid lipid nanoparticles slns serve as an alternative carrier system for traditional colloidal carriers like polymeric microparticles, nanoparticles, liposomes and emulsions. Solid lipid microparticles were produced from fhco using the particle formation unit shown in fig. In the following years, extensive work and experiments with solid lipids resulted in the invention of lipid based solid particles in the submicron range by the groups of westesen, muller and gasco 2 4.
Formation of solid lipid microparticles from fully. Almeida research institute for medicines and pharmaceutical sciences imed. Solid lipid nanoparticles sln, colloidal drug carriers, homogenization, tem, pcs, biodistribution. Microvesicles ectosomes, or microparticles are a type of extracellular vesicle ev that are released from the cell membrane. The stability and biological activity of the drug must not be affected by the processing parameters employed in the fabrication of drugloaded microparticles. Formation of bioactivecarrier hollow solid lipid micro and. The lipid matrix itself determines the particles pharmaceutical properties as it is the structure that stores, transports and releases the drug.
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